Dihydropyrazine-Induced Inactivation of Glyceraldehyde-3-phosphate Dehydrogenase
نویسندگان
چکیده
منابع مشابه
Dihydropyrazine-induced inactivation of glyceraldehyde-3-phosphate dehydrogenase.
Dihydropyrazine (DHP), which is produced during the Maillard reaction, generates radicals that not only cause breakage of chromosomal DNA leading to mutagenic lesions but also induce oxidative damage to cellular proteins. In the present study, we show that three DHP derivatives, which generated superoxide anions, caused inhibition of glyceraldehyde-3-phosphate dehydrogenase (GAPDH). SH-compound...
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ژورنال
عنوان ژورنال: Biological and Pharmaceutical Bulletin
سال: 2010
ISSN: 0918-6158,1347-5215
DOI: 10.1248/bpb.33.379